26 Aug 2019 Primary Hyperoxaluria is a rare autosomal recessive disorder leading to markedly elevated levels of endogenous oxalate in plasma and urine.

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Primary hyperoxaluria (PH) is a rare genetic metabolic disorder. There are three forms of PH (type 1, 2, and 3), caused by different enzyme deficiencies leading to excessive oxalate production. Oxalate cannot be metabolized by human cells. Elimination occurs primarily via the kidneys.

between Week 5 and Week 10 of the study) in the initial part of the study and then bimonthly during years 1 and 2 of continued treatment and every 3 to 4 months throughout year 3 of the continued Background: Primary hyperoxaluria (PH) is a rare, genetic disorder which involves the overproduction of endogenous oxalate, leading to hyperoxaluria, recurrent urolithiasis and/or progressive nephrocalcinosis and eventually resulting in kidney failure and systemic oxalosis. OxThera holds worldwide rights for compositions and methods of use for treatment of hyperoxaluria. OxThera currently has two products in its pipeline: Oxabact® for the treatment of Primary Hyperoxaluria, and Oxazyme®, an oxalate decarboxylase, for the prevention of oxalate malabsorption and recurring kidney stones in Secondary Hyperoxaluria. Patients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy. Progression to kidney failure often develops over a number of years, and is associated with systemic oxalosis, intensive dialysis, and often combined kidney and liver transplantation.

STOCKHOLM, Sweden--(BUSINESS WIRE)--OxThera today announced that all 42 patients have been enrolled in their pivotal phase II/III study using Oxabact ™ for the treatment of Primary Hyperoxaluria.

Currently pharmaceutical treatment is not available and median age of death is 30, if not treated. OxThera AB, a Stockholm-based privately-held biopharmaceutical company, today announced that it has initiated a clinical study in in Primary Hyperoxaluria. This announcement bolsters the Company's position as a leader in developing therapies for hyperoxaluria, a debilitating condition that, if untreated, leads to kidney damage and end-stage renal disease.

STOCKHOLM, SWEDEN – June 20, 2019. OxThera AB, a biopharmaceutical company dedicated to improve the lives of people living with Primary Hyperoxaluria, today announced that the first patients in a Phase 3 study of Oxabact® have completed the study and transitioned to an open-label extension part.

The patents will secure the pharmaceutical composition and the method 2019-06-21 Stockholm - 6 April 2020. OxThera AB, a privately-held biopharmaceutical company dedicated to improving the lives of people with Primary Hyperoxaluria (PH), ann OxThera holds worldwide rights for compositions and methods of use for treatment of hyperoxaluria. OxThera currently has two products in its pipeline: Oxabact® for the treatment of Primary Hyperoxaluria, and Oxazyme®, an oxalate decarboxylase, for the prevention of oxalate malabsorption and recurring kidney stones in Secondary Hyperoxaluria. 2020-04-06 OxThera is a biopharmaceutical company with products in late stage clinical development focusing on Primary and Secondary Hyperoxaluria. OxThera currently has two products in its pipeline: Oxabact® for the treatment of Primary Hyperoxaluria, and Oxazyme®, an oxalate decarboxylase, for dietary hyperoxaluria and prevention of kidney stones. OxThera AB is a Swedish biotech company developing a new treatment for primary hyperoxaluria - a rare genetic and devastating disease with fatal outcomes. Currently pharmaceutical treatment is not Background: Primary hyperoxaluria (PH) is a rare, genetic disorder which involves the overproduction of endogenous oxalate, leading to hyperoxaluria, recurrent urolithiasis and/or progressive nephrocalcinosis and eventually resulting in kidney failure and systemic oxalosis.

[ Time Frame: 6 weeks of active treatment (i.e.
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OxThera announces completion of recruitment in Phase 3 ePHex study with Oxabact® in patients with primary hyperoxaluria Mon, Apr 06, 2020 07:40 CET OxThera AB, a privately-held biopharmaceutical company dedicated to improving the lives of people with Primary Hyperoxaluria (PH), announced today that it has completed enrollment in its Oxabact ePHex phase III study. OxThera initiates extension part of a Phase 3 study of Oxabact in Primary Hyperoxaluria Thu, Jun 20, 2019 10:00 CET OxThera AB, a biopharmaceutical company dedicated to improve the lives of people living with Primary Hyperoxaluria, today announced that the first patients in a Phase 3 study of Oxabact® have completed the study and transitioned to an open-label extension part. OxThera initiates extension part of a Phase 3 study of Oxabact in Primary Hyperoxaluria (Cision) 2019-06-20 10:00 OxThera AB, a biopharmaceutical company dedicated to improve the lives of people living with Primary Hyperoxaluria, today announced that the first patients in a Phase 3 study of Oxabact® have completed the study and transitioned to an open-label extension part. ePHex - An OxThera Clinical Trial in Primary Hyperoxaluria, Stockholm, Sweden. 39 likes.

Stockholm - 6 April 2020. OxThera AB, a privately-held biopharmaceutical company dedicated to improving the lives of people with Primary Hyperoxaluria (PH), ann Primär hyperoxaluri är en sällsynt ärftlig sjukdom som leder till markant förhöjda nivåer av oxalat i plasma och urin. Höga oxalatnivåer resulterar i njurskador, inklusive kristallutfällning av kalciumoxalat i njurar och andra vävnader. Om sjukdomen inte behandlas kan den orsaka njur- och hjärtsvikt och för tidig död.
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Primary hyperoxaluria is a rare autosomal recessive inherited disorder of glyoxylate metabolism that causes an endogenous overproduction of oxalate. Oxalate cannot be degraded in humans and is mostly eliminated by the kidneys. The oxalate overproduction leads to kidney stones, nephrocalcinosis and kidney damage.

Oxalobacter formigenes is effective at lowering plasma oxalate levels in patients with primary hyperoxaluria who are on dialysis. Ledande sponsor: OxThera. OC5 for patients with primary hyperoxaluria who completed study the parent double-blind, placebo-controlled study OC5-DB-02 Ledande sponsor: OxThera.

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OxThera AB, a Stockholm-based privately-held biopharmaceutical company, today announced that the Phase 3 study with Oxabact ® in Primary Hyperoxaluria (PH) is now fully open for recruitment. All clinics participating in the study are approved by Competent authorities in Europe and US and are initiating patient screening. ‘We are pleased to announce that we are now fully open for enrolment

Ultimately, our goal is to improve quality of life and to extend life expectancy of patients with primary hyperoxaluria. OxThera is developing a novel treatment, Oxabact, for Primary hyperoxaluria (PH), a severe and often fatal disease in children, and where there are currently no available therapies. The… Read More Matthew Gantz Appointed CEO of Oxthera 2017-07-05 Primary hyperoxaluria is a rare autosomal recessive inherited disorder of glyoxylate metabolism that causes an endogenous overproduction of oxalate. Oxalate cannot be degraded in humans and is mostly eliminated by the kidneys. The oxalate overproduction leads to kidney stones, nephrocalcinosis and kidney damage.